Nuremberg is the second-largest city of the German state of Bavaria after its capital Munich, and its 518,370 inhabitants make it the 14th-largest city in Germany.

Regensburg, a Bavarian city on the Danube River in southeast Germany, is known for its well-preserved medieval core. The 12th-century Stone Bridge, a 310m-long icon with 16 arches, crosses the river to the old town. The 13th-century Regensburg Cathedral, a twin-spired Gothic landmark, is home to the Regensburger Domspatzen choir. Walhalla, a Parthenon replica just east of the city, honors illustrious Germans.

Passau, a German city on the Austrian border, lies at the confluence of the Danube, Inn and Ilz rivers. Known as the Three Rivers City, it’s overlooked by the Veste Oberhaus, a 13th-century hilltop fortress housing a city museum and observation tower. The old town below is known for its baroque architecture, including St. Stephen’s Cathedral, featuring distinctive onion-domed towers and an organ with 17,974 pipes.

Melk is an Austrian town on the River Danube, west of Vienna. It’s known for the 11th-century Melk Abbey, a vast monastery built high above the town. Gold statuary adorns its domed Abbey Church, and the huge library houses medieval manuscripts. The Marmorsaal is a baroque hall with a ceiling fresco and red marble walls. South of Melk, gardens surround Renaissance Schallaburg Castle, which hosts cultural exhibitions.

Dürnstein is a small town on the Danube river in the Krems-Land district, in the Austrian state of Lower Austria. It is one of the most-visited tourist destinations in the Wachau region and also a well-known wine growing area.

Vienna, Austria’s capital, lies in the country’s east on the Danube River. Its artistic and intellectual legacy was shaped by residents including Mozart, Beethoven and Sigmund Freud. The city is also known for its Imperial palaces, including Schönbrunn, the Habsburgs’ summer residence. In the MuseumsQuartier district, historic and contemporary buildings display works by Egon Schiele, Gustav Klimt and other artists.

Bratislava, the capital of Slovakia, is set along the Danube River by the border with Austria and Hungary. It’s surrounded by vineyards and the Little Carpathian mountains, crisscrossed with forested hiking and cycling trails. The pedestrian-only, 18th-century old town is known for its lively bars and cafes. Perched atop a hill, the reconstructed Bratislava Castle overlooks old town and the Danube

Budapest, Hungary’s capital, is bisected by the River Danube. Its 19th-century Chain Bridge connects the hilly Buda district with flat Pest. A funicular runs up Castle Hill to Buda’s Old Town, where the Budapest History Museum traces city life from Roman times onward. Trinity Square is home to 13th-century Matthias Church and the turrets of the Fishermen’s Bastion, which offer sweeping views.

Budapest, Hungary’s capital, is bisected by the River Danube. Its 19th-century Chain Bridge connects the hilly Buda district with flat Pest. A funicular runs up Castle Hill to Buda’s Old Town, where the Budapest History Museum traces city life from Roman times onward. Trinity Square is home to 13th-century Matthias Church and the turrets of the Fishermen’s Bastion, which offer sweeping views.